DNA Nanostructures in Pharmaceutical Applications. Issue 36 (22nd September 2022)

• Record Type: Journal Article
• Authors: John, Jinju; Joseph, Ajinsh; Kadavan, Liya J.; Prabhu, Prathibha S.; Prabhu, Deepak J.; John, Franklin; George, Jinu
• Is Part Of: ChemistrySelect. Volume 7:Issue 36(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-22
• Subjects: Co-delivery -- DNA nanostructures -- DOX -- mRNA -- siRNA; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202203004
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: DNA nanostructures have evolved in various ways throughout the years since their discovery, including their structures and functions. Because DNA is a component of the biological system, it may be utilized to deliver therapeutic molecules without causing any harm to the body. For delivery, DNA nanostructures offer several benefits over conventional nanomaterials such as liposomes, polymers gold nanoparticles, carbon materials, etc. Various therapeutic molecules like drugs, nucleic acids, proteins, and a combination of these agents can be delivered with the help of DNA nanostructures.Because of the ease with which nanostructures can be synthesized through self‐assembly and the ability to form a variety of shapes, they have found widespread application in biomedical fields. In this review, we will look at the different classes of compounds that are delivered via DNA nanostructures. Abstract : DNA nanostructures can be used to deliver various therapeutic agents including doxorubicin, paclitaxel, siRNA, mRNA, aptamer, and CpG oligonucleotide to facilitate chemotherapy, gene therapy, and immunotherapy.