A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism. (25th September 2022)

• Record Type: Journal Article
• Authors: MacLean, Margaret R.; Pandya, Divya; Swietlik, Emilia M.; Denver, Nina; Mair, Kirsty; Morrell, Nicholas W.; Gräf, Stefan
• Is Part Of: Pulmonary circulation. Volume 12:Number 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-25
• Subjects: estrogen -- estrogen metabolites -- obesity -- pulmonary hypertension -- sex; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1002/pul2.12139
• Languages: English
• ISSNs: 2045-8932

Abstract

Abstract: The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism.