Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition. Issue 42 (13th August 2022)

• Record Type: Journal Article
• Authors: Zhu, Jiaqian; Yuan, Huihui; Zhang, Shunqi; Hao, Xiang; Lan, Minbo
• Is Part Of: Journal of applied polymer science. Volume 139:Issue 42(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-13
• Subjects: antibacterial -- anti‐fouling -- hydrophilicity -- polydopamine fast deposition -- surface modification; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.53009
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Implanted medical devices are widely used in clinic for disease treatment, but they generally suffer from the bio‐fouling problem which leads to the reduction of service life and loss of therapeutic effects. Herein, an eco‐friendly method based on polydopamine (PDA) fast deposition is developed to construct anti‐fouling and antibacterial surface on polyurethane (PU). The self‐adhesive layer of PDA contributes to the formation of a platform with active sites for further antibacterial and hydrophilic modification. Polyhexamethylguanidine (PHMG) as antibacterial ingredient and chondroitin sulfate (CS) as hydrophilic component covalently bind on PDA platform, which successively helps to form PU‐PDA/PHMG/CS. The resultant surface demonstrates the excellent property of anti‐protein adsorption (96.8%), anti‐bacterial ability (99.9%), and cell compatibility (95.0%), which would have great potential for medical application. Abstract : This article develops an antifouling and antibacterial coatings on PU surface based on PDA fast deposition. The coatings contain antibacterial agents polyhexamethyleneguanidine (PHMG) and hydrophilic polysaccharide chondroitin sulfate (CS), which endow surface with excellent anti‐protein adsorption property and antibacterial ability. And the whole preparation process is environmentally friendly, which ensures the coatings good bio‐compatibility.