Innovative Approach to Preparing Radial Artery Cocktails in Response to Manufacturer Shortages of Nitroglycerin and Verapamil. Issue 7 (July 2014)

• Record Type: Journal Article
• Authors: Parbhoo, Rupal K.; Wetz, Karen; Tschampel, Marva; Pompili, Vincent; Schenko, Elena; Mavko, Lou; Blais, Danielle
• Is Part Of: Hospital pharmacy. Volume 49:Issue 7(2014)
• Page Start: 628
• Page End: 633
• Publication Date: 2014-07
• Subjects: verapamil -- cardiac catheterization -- drug shortage -- nitroglycerin -- radial artery spasm -- stability -- transradial; Hospital pharmacies -- Periodicals; Pharmacy Service, Hospital; Hospital pharmacies; Periodicals; Periodicals; 615.1
• DOI: 10.1310/hpj4907-628
• Languages: English
• ISSNs: 0018-5787

Abstract

Background: Transradial access has gained popularity over transfemoral access for cardiac catheterization, because of the decreased risk of bleeding, time to ambulation, and length of stay leading to improved patient satisfaction. One disadvantage of the radial artery approach is vasospasm, which can be prevented with the administration of verapamil and nitroglycerin in a pre- and postradial cocktail. Unfortunately, there have been manufacturer shortages for both of these medications. Methods: The utilization of radial artery cocktails and other nitroglycerin compounding practices were evaluated in response to cost containment and waste reduction initiatives and to medication shortages. Results: A modified process for supplying verapamil and nitroglycerin for the transradial approach via separate syringes enabled physicians to have quick access to the medications and to customize the cocktail based on the patient's needs. This process also decreased costs and minimized wastage. The change in practice decreased waste from 44% for preradial cocktail syringes and 66% for postradial cocktail syringes to 8.7%. Discussion: This process for supplying the medications necessary to perform a radial artery catheterization and intracoronary nitroglycerin has allowed for conservation of commercial product supply.