Multicentric Giant Cell Tumor of the Fourth and Fifth Metacarpals with Lung Metastases. (September 2014)

• Record Type: Journal Article
• Authors: Naam, Nash H.; Jones, Steven L.; Floyd, Justin; Memisoglu, Esat I.
• Is Part Of: Hand. Volume 9:Number 3(2014)
• Page Start: 389
• Page End: 392
• Publication Date: 2014-09
• Subjects: Giant cell -- Multicentric -- Metacarpal -- Tumor; Hand -- Surgery -- Periodicals; Hand -- Surgery; Periodicals; 617.57005
• DOI: 10.1007/s11552-013-9574-x
• Languages: English
• ISSNs: 1558-9447

Abstract

Giant cell tumors of bone (GCTB) are generally benign neoplasms, but recently, some authors consider them to be low-grade malignant neoplasms because they have a relatively high rate of recurrence and at least some potential for metastases. The majority of GCTB are unifocal, and less than 1 % are multicentric. We report a rare case of a multicentric GCTB arising simultaneously in the non-dominant fourth and fifth metacarpals of a 25-year-old female. The patient underwent ray amputation of the two involved digits, and the surgical margins were histologically negative for tumor. The tumor had the classic histologic appearance of a benign GCTB. A year after the amputation, the patient developed pulmonary metastasis which was treated with pulmonary lobe resection. She is currently over 2.5 years ***post-surgical treatment of the primary lesion with no evidence of local recurrence or distant metastasis.