Electrolyte-free electrochemical C–H trifluoromethylation of 2-pyridones under batch and flow conditions. Issue 19 (22nd September 2022)

• Record Type: Journal Article
• Authors: Leclercq, Elise; Moncomble, Aurélien; Debavelaere, Céline; Beaucamp, Mathieu; Penhoat, Maël; Chausset-Boissarie, Laëtitia
• Is Part Of: Green chemistry. Volume 24:Issue 19(2022)
• Page Start: 7388
• Page End: 7394
• Publication Date: 2022-09-22
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d2gc02326a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An environmentally friendly electrochemical process for the direct trifluoromethylation of 2-pyridones with a broad substrate scope has been developed. Abstract : Herein, we report direct C3 trifluoromethylation of 2-pyridones including unprotected derivatives by an electrochemical approach using the readily available Langlois reagent as the CF3 source in the absence of electrolytes. The trifluoromethylation under transition metal- and oxidant-free conditions occurred site-selectively to give the desired products in moderate to good yields under ambient conditions. Interestingly, significant acceleration rates, improved yields and selectivities as well as reduced energy consumption were achieved under microfluidic conditions.