A multi-omics study of the anti-cancer effect of a ferulic acid derivative FA-30. (10th August 2022)

• Record Type: Journal Article
• Authors: Wang, Dongyao; Guo, Dandan; Tang, Yuxiao; Qi, Minyu; Fang, Jiahao; Zhang, Ying; Chai, Yifeng; Cao, Yan; Lv, Diya
• Is Part Of: Molecular omics. Volume 18:Number 8(2022)
• Page Start: 805
• Page End: 813
• Publication Date: 2022-08-10
• Subjects: Molecular biology -- Periodicals; Biochemistry -- Periodicals; Biological systems -- Periodicals; Molecular Biology; Computational Biology; Biochemistry; Biological systems; Molecular biology; Periodicals; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals
• DOI: 10.1039/d2mo00025c
• Languages: English
• ISSNs: 2515-4184

Abstract

Abstract : The active ingredients of Traditional Chinese Medicine are an important source of bioactive molecules and play an important role in the research and development of innovative drugs. Abstract : The active ingredients of Traditional Chinese Medicine are an important source of bioactive molecules and play an important role in the research and development of innovative drugs. FA-30, which is a derivative of natural product ferulic acid, inhibited cervical cancer cell proliferation and induced apoptosis as well. To understand the underlying mechanisms of FA-30, a complementary multi-omics study was conducted. Cysteine and methionine metabolism and aminoacyl-tRNA biosynthesis pathways were significantly changed both at the metabolic level and proteomic level. This may help us to get a better understanding of cervical cancer and FA-30 at the same time.