Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management. Issue 37 (27th April 2022)

• Record Type: Journal Article
• Authors: Wu, Lihuang; He, Yiyan; Mao, Hongli; Gu, Zhongwei
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 37(2022)
• Page Start: 7148
• Page End: 7160
• Publication Date: 2022-04-27
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb00591c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : This review provides the recent progress, intrinsic interactions between structures and bioactive performances, current limitations and future directions of bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management. Abstract : Due to their inherent and tunable biomechanical and biochemical performances, bioactive hydrogels based on polysaccharides and peptides have shown attractive potential for wound management. In this review, the recent progress of bioactive hydrogels prepared by polysaccharides and peptides for soft tissue wound management is overviewed. Meanwhile, we focus on the elaboration of the relationship between chemical structures and inherent bioactive functions of polysaccharides and peptides, as well as the strategies that are taken for achieving multiple wound repairing effects including hemostasis, adhesion, wound contraction and closure, anti-bacteria, anti-oxidation, immunomodulation, molecule delivery, etc. Some innovative and important works are well introduced as well. In the end, current study limitations, clinical unmet needs, and future directions are discussed.