Development of a novel phosphoramidite-selenide ligand for Pd-catalyzed asymmetric allylic substitution. Issue 37 (14th September 2022)

• Record Type: Journal Article
• Authors: Feng, Bin; Fang, Pei-Wen; Lan, Gui-Man; Peng, Li-Yan; Liang, Lu-Fang; You, Ge-Yun
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 37(2022)
• Page Start: 7415
• Page End: 7418
• Publication Date: 2022-09-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01249a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel chiral P, Se-heterodonor ligand has been designed and prepared through an efficient and simple operation. This ligand can be successfully applied to Pd-catalyzed asymmetric allylic substitution with C- and N-nucleophiles. Abstract : A novel chiral P, Se-heterodonor ligand has been designed and prepared through an efficient and simple operation. This ligand can be successfully applied to Pd-catalyzed asymmetric allylic substitution with C- and N-nucleophiles, producing a diverse range of chiral allylic products in high yields and enantioselectivities (up to 99% yield and 95% ee).