Update on Immune Mechanisms in Hypertension. (15th June 2022)

• Record Type: Journal Article
• Authors: Navaneethabalakrishnan, Shobana; Smith, Hannah L; Arenaz, Cristina M; Goodlett, Bethany L; McDermott, Justin G; Mitchell, Brett M
• Is Part Of: American journal of hypertension. Volume 35:Number 10(2022)
• Page Start: 842
• Page End: 851
• Publication Date: 2022-06-15
• Subjects: blood pressure -- hypertension -- immunity -- inflammation -- lymphocytes; Hypertension -- Periodicals; 616.132005
• DOI: 10.1093/ajh/hpac077
• Languages: English
• ISSNs: 0895-7061

Abstract

Abstract: The contribution of immune cells in the initiation and maintenance of hypertension is undeniable. Several studies have established the association between hypertension, inflammation, and immune cells from the innate and adaptive immune systems. Here, we provide an update to our 2017 American Journal of Hypertension review on the overview of the cellular immune responses involved in hypertension. Further, we discuss the activation of immune cells and their contribution to the pathogenesis of hypertension in different in vivo models. We also highlight existing gaps in the field of hypertension that need attention. The main goal of this review is to provide a knowledge base for translational research to develop therapeutic strategies that can improve cardiovascular health in humans. Graphical Abstract: