Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study . (10th February 2022)

• Record Type: Journal Article
• Authors: Liebenberg, Lenine J P; Passmore, Jo Ann S; Osman, Farzana; Jewanraj, Janine; Mtshali, Andile; Gerardo Garcia-Lerma, J; Heneine, Walid; Holder, Angela; Archary, Derseree; Ngcapu, Sinaye; Sivro, Aida; Mansoor, Leila E; Abdool Karim, Quarraisha; Abdool Karim, Salim S; McKinnon, Lyle R
• Is Part Of: Clinical infectious diseases. Volume 75:Number 6(2022)
• Page Start: 1088
• Page End: 1091
• Publication Date: 2022-02-10
• Subjects: immune activation -- genital inflammation -- HIV -- tenofovir -- dATP; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac115
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.