Performance of the Sofia SARS-CoV-2 Rapid Antigen Test in Symptomatic and Asymptomatic Pediatric Patients. Issue 9 (24th May 2022)

• Record Type: Journal Article
• Authors: Freeman, Megan Culler; Freeman, Tanner J; Iagnemma, Jennifer; Rasmussen, Jayne; Heidenreich, Kelly; Wells, Alan; Hoberman, Alejandro; Mitchell, Stephanie L
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 11:Issue 9(2022)
• Page Start: 417
• Page End: 421
• Publication Date: 2022-05-24
• Subjects: antigen assay -- COVID-19 -- pediatrics -- rapid test -- RT-PCR -- SARS-CoV-2; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piac035
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: The sensitivity and specificity of SARS-CoV-2 antigen tests have not been widely assessed in children. We evaluated children presenting to outpatient care with Quidel Sofia SARS-CoV-2 antigen test (Sofia-Ag-RDT) compared against Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV reverse transcriptase-polymerase chain reaction test from November 2020 to April 2021. Sofia-Ag-RDT had the highest sensitivity in symptomatic (82%; 95% confidence interval, 68%-91%) children. Abstract : Quidel Sofia SARS-CoV-2 antigen test has better diagnostic performance for SARS-CoV-2 infection in symptomatic children than in asymptomatic children.