Dynamics of the Cellular and Humoral Immune Response After BNT162b2 Messenger Ribonucleic Acid Coronavirus Disease 2019 (COVID-19) Vaccination in COVID-19-Naive Nursing Home Residents. (13th September 2021)

• Record Type: Journal Article
• Authors: Van Praet, Jens T; Vandecasteele, Stefaan; De Roo, Anneleen; Vynck, Matthijs; De Vriese, An S; Reynders, Marijke
• Is Part Of: Journal of infectious diseases. Volume 224:Number 10(2021)
• Page Start: 1690
• Page End: 1693
• Publication Date: 2021-09-13
• Subjects: BNT162b2 mRNA COVID -- 19 vaccine -- COVID -- 19 -- nursing home residents -- SARS -- CoV -- 2; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab458
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials. Abstract : In COVID-19-naive nursing home residents, the humoral and cellular immune response after BNT162b2 mRNA COVID-19 vaccination declines after 4 weeks and remains lower than those of healthcare workers after 24 weeks.