Giant Tumefactive Perivascular Spaces in a Patient Presenting With a First Seizure. (6th September 2022)

• Record Type: Journal Article
• Authors: Loo Yong Kee, Kimberley Kim Foon; Jan, Wajanat; Carswell, Christopher James
• Is Part Of: Neurology. Volume 99:Number 10(2022)
• Page Start: 428
• Page End: 429
• Publication Date: 2022-09-06
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000200997
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : A 53-year-old man with hypertension presented with a generalized tonic-clonic seizure. General and neurologic examination, serology, and ECG were normal. Brain MRI revealed asymmetrical tumefactive perivascular spaces (PVSs) with a right frontal mass effect (Figure). PVSs are pial-lined, interstitial fluid–filled structures that may be detected incidentally. 1 Giant PVSs are rare, and imaging appearances can be dramatic. PVSs are more common in people with hypertension. 1 PVSs are more asymmetrically clustered in those with focal epilepsy than controls, 2 suggesting a possible role in pathogenesis. In this case, EEG showed slow and sharp waves in the right frontotemporal lobes, suggesting possible PVS-related seizure susceptibility.