Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Issue 4 (26th October 2022)

• Record Type: Journal Article
• Authors: Stone, Scellig S. D.; Park, Eun-Hyoung; Bolton, Jeffrey; Harini, Chellamani; Libenson, Mark H.; Rotenberg, Alexander; Takeoka, Masanori; Tsuboyama, Melissa; Pearl, Phillip L.; Madsen, Joseph R.
• Is Part Of: Neurosurgery. Volume 91:Issue 4(2022)
• Page Start: 583
• Page End: 589
• Publication Date: 2022-10-26
• Subjects: Causal connectivity -- Epilepsy surgery -- Interictal Intracranial EEG -- Seizure networks -- Stereoelectroencephalography -- Surgical planning; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1227/neu.0000000000002079
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract : BACKGROUND: Stereoelectroencephalography (sEEG) facilitates electrical sampling and evaluation of complex deep-seated, dispersed, and multifocal locations. Granger causality (GC), previously used to study seizure networks using interictal data from subdural grids, may help identify the seizure-onset zone from interictal sEEG recordings. OBJECTIVE: To examine whether statistical analysis of interictal sEEG helps identify surgical target sites and whether surgical resection of highly ranked nodes correspond to favorable outcomes. METHODS: Ten minutes of extraoperative recordings from sequential patients who underwent sEEG evaluation were analyzed (n = 20). GC maps were compared with clinically defined surgical targets using rank order statistics. Outcomes of patients with focal resection/ablation with median follow-up of 3.6 years were classified as favorable (Engel 1, 2) or poor (Engel 3, 4) to assess their relationship with the removal of highly ranked nodes using the Wilcoxon rank-sum test. RESULTS: In 12 of 20 cases, the rankings of contacts (based on the sum of outward connection weights) mapped to the seizure-onset zone showed higher causal node connectivity than predicted by chance ( P ≤ .02). A very low aggregate probability ( P < 10 −18, n = 20) suggests that causal node connectivity predicts seizure networks. In 8 of 16 with outcome data, causal connectivity in the resection was significantly greater than in the remaining contacts ( P ≤ .05). We found a significant association between favorable outcome and the presence of highly ranked nodes in the resection ( P < .05). CONCLUSION: Granger analysis can identify seizure foci from interictal sEEG and correlates highly ranked nodes with favorable outcome, potentially informing surgical decision-making without reliance on ictal recordings.