Prevalence of neutropenia among adult Arabs in Qatar: Relation to other hematological parameters and anthropometric data. Issue 36 (9th September 2022)

• Record Type: Journal Article
• Authors: Yassin, Mohamed A.; Soliman, Ashraf T.; Hmissi, Saloua M.; Abdulla, Mohammad A.J.; Itani, Maya; Alamami, Ans A.; Aldapt, Mahmood B.; Suliman, Aasir M.; Ibrahim, Ezzeddin A.; Mohamed, Mouhand F.H.; Rozi, Waail; Mohamed, Shehab F.; Chandra, Prem; Nashwan, Abdulqadir J.
• Is Part Of: Medicine. Volume 101:Issue 36(2022)
• Page Start: e30431
• Publication Date: 2022-09-09
• Subjects: absolute neutrophil count -- complete blood count -- ethnicity -- neutropenia -- reference range; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000030431
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Neutropenia ranges from a normal variant to life-threatening acquired and congenital disorders. This study aims at providing baseline information regarding the prevalence and spectrum of neutropenia in the Arab blood donors who are living in Qatar. This retrospective cohort study was conducted to review the data of healthy Arab individuals (≥18 years) who donated blood between January 1, 2015 to May 15, 2019. A complete blood count was performed using automated analyzers. The prevalence of neutropenia was 10.7%. The prevalence in females was 32% and in males, it was 6%. Absolute neutrophil count (ANC) below 1 × 10 9 /L was detected in 10% of Arab females and 1.8 % of Arab males. In females, the neutropenic group had significantly lower hemoglobin (Hb) levels and higher red cell distribution width, and lower total white blood cells and lymphocyte counts ( P < .001) compared to the group with ANC > 1.5 × 10 9 /L. Significant correlations were found between the ANC and Hb ( r = 0.33, P < .05) and ANC and total white blood cells ( r = 0.45, P < .01). The prevalence of neutropenia is considerably high in Arab adult females compared to other ethnic groups. Besides the genetic constitution of Arabs, the lower Hb and higher red cell distribution width in females suggest that iron deficiency could contribute to the development of neutropenia.