Proteinuria in Deceased Kidney Transplant Donors for Prediction of Chronic Lesions in Pretransplant Biopsies: A Prospective Observational Study. Issue 10 (11th April 2022)

• Record Type: Journal Article
• Authors: Haupenthal, Frederik; Kläger, Johannes; Bauernfeind, Florian; Heinzel, Andreas; Doberer, Konstantin; Mayer, Katharina; Naar, Luis; Eigenschink, Michael; Hu, Karin; Regele, Heinz; Szekeres, Thomas; Berlakovich, Gabriela; Reindl-Schwaighofer, Roman; Bond, Gregor
• Is Part Of: Transplantation. Volume 106:Issue 10(2022)
• Page Start: 2044
• Page End: 2051
• Publication Date: 2022-04-11
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000004134
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Background: Pretransplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors are not available. Methods: In this prospective study, we analyzed 147 pretransplant kidney biopsies from 88 deceased adult donors procured and transplanted consecutively at the Medical University Vienna between July 2017 and May 2020. Lesions in each renal compartment were scored from 0 to 5 with each ascending score representing a 20% increase in organ damage. A chronic lesions score was calculated including glomerulosclerosis, intima fibrosis, hyalinosis, interstitial fibrosis, and tubular atrophy. Results: The median chronic lesion score was 2 (interquartile range [IQR] 1–4) and the median donor urinary protein to creatinine ratio (UPCR) was 382 mg/dL (IQR 222–703). There was a positive correlation between UPCR and number of chronic lesions (β 0.15, 95% confidence interval, 0.03-0.28; P = 0.019). Biopsies with 2 or more lesions had a median UPCR of 486 mg/dL (IQR 251–717) compared with 274 mg/dL (IQR 211–556; P = 0.016) in biopsies with <2 lesions. The risk for detection of 2 or more lesions rose by 18% for every log increase in UPCR (risk ratio 1.18, 95% confidence interval, 1.03-1.25; P = 0.017). Multivariable and sensitivity analysis revealed an independent and robust association between chronic lesions and UPCR. Conclusions: Donor UPCR is associated with chronic lesions in pretransplant deceased donor kidney graft biopsies. This finding justifies further investigation of donor proteinuria for the assessment of organ quality and outcome.