Enhancing Skin Uptake of Topical Antioxidants With 1, 440-nm Nonablative Fractional Diode Laser Pretreatment. Issue 9 (29th September 2022)

• Record Type: Journal Article
• Authors: Wang, Jordan V.; Friedman, Paul M.; Rodeberg, Deirdre; Konda, Adarsh; Parker, Catherine; Geronemus, Roy G.
• Is Part Of: Dermatologic surgery. Volume 48:Issue 9(2022)
• Page Start: 927
• Page End: 931
• Publication Date: 2022-09-29
• Subjects: Skin -- Surgery -- Periodicals; Skin -- Diseases -- Surgery -- Periodicals; 617.477
• DOI: 10.1097/DSS.0000000000003531
• Languages: English
• ISSNs: 1076-0512

Abstract

Abstract : BACKGROUND: Energy-based devices, such as nonablative lasers, are a promising method to enhance the delivery and absorption of topically applied molecules. OBJECTIVE: To characterize ex vivo uptake of common antioxidant topicals after pretreatment with a nonablative laser wavelength. MATERIALS AND METHODS: Using donor human skin tissue, uptake of 3 topical antioxidants was analyzed (C E Ferulic with 15% l -ascorbic acid [15% vitamin C serum], Phloretin CF with ferulic acid [10% vitamin C serum], and Phyto+ [botanical serum]; SkinCeuticals, Dallas, TX; 2010 formulations) after pretreatment with a 1, 440-nm nonablative fractional diode laser. RESULTS: Pretreatment with the 1, 440-nm laser enhanced uptake of 15% and 10% vitamin C serums by approximately 10 and 21 times, respectively, compared to controls. Laser pretreatment also enhanced uptake of botanical serum by approximately 6 times relative to controls. Permeation of vitamin C and botanical serums was also enhanced through laser pretreatment. CONCLUSION: Nonablative laser pretreatment increased uptake and permeation of topical antioxidants. Optimizing treatment requires consideration of the device and treatment parameters as well as the properties of the topical formulation.