Anchietins A–E: 30-norfriedelane-type triterpenes from Anchietea pyrifolia. (November 2022)

• Record Type: Journal Article
• Authors: Yoneda, Yukiyasu; Yahagi, Tadahiro; Harada, Kenichi; Okamoto, Yasuko; Motai, Sumiaki; Matsuzaki, Keiichi; Kubo, Miwa; Fukuyama, Yoshiyasu; Ohsaki, Ayumi
• Is Part Of: Phytochemistry. Volume 203(2022)
• Publication Date: 2022-11
• Subjects: Anchietia pyrifolia -- Violaceae 30-Norfriedelane Triterpenoid -- NO production -- iNOS; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113388
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Five undescribed norfriedelane triterpenoids, anchietins A-E, along with three known norfriedelane triterpenoids, 21β-hydroxycaloncobalactone, and welwitschiilactones B and C, were isolated from the vine of Anchietia pyrifolia . The compounds were characterized by spectroscopic and crystallographic methods, including 2D NMR spectroscopy and single crystal X-ray crystallography. The isolated compounds were evaluated for the cytotoxic activity against HeLa and HL60 cells and for the inhibitory activity against lipopolysaccharide-induced NO production. Further, inhibitory effects on the inducible nitric oxide synthase mRNA expression levels were also assessed. Graphical abstract: Image 1 Highlights: Five new norfriedelane triterpenoids, anchietines A-E were isolated from Anchietia pyrifolia. The isolated compounds were assessed for cytotoxicity against HL-60 cells. The isolated compounds were evaluated for LPS-induced NO production inhibitory activity. The inhibitory effects of 1 for the expression level of iNOS mRNA was assessed.