Additive-free aerobic oxidation of hydroazobenzenes: Access to azobenzenes and epoxidation of enones. (12th October 2022)

• Record Type: Journal Article
• Authors: Lin, Yu; Wu, Hao; Liu, Ziang; Li, Jin; Cai, Rui; Hashimoto, Makoto; Wang, Lei
• Is Part Of: Tetrahedron letters. Volume 108(2022)
• Publication Date: 2022-10-12
• Subjects: Aerobic oxidation -- Azobenzenes -- Epoxidation of enones -- Hydrogen peroxide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154132
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: We reported herein a highly effective approach to prepare azobenzenes from hydroazobenzenes via an additive-free aerobic oxidation strategy. This method smoothly produces azobenzenes and heterocyclic azo derivatives in DMF at 80 °C under oxygen atmosphere. It features excellent yield, functional group tolerance and convenience. The broad application of this method is further proved by gram scale synthesis and the epoxidation of enones.