Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects. (October 2022)

• Record Type: Journal Article
• Authors: Bagdasarov, Armen; Roberts, Kenneth; Bréchet, Lucie; Brunet, Denis; Michel, Christoph M.; Gaffrey, Michael S.
• Is Part Of: Developmental cognitive neuroscience. Volume 57(2022)
• Publication Date: 2022-10
• Subjects: EEG microstates -- Resting-state networks -- Brain development -- Children -- Age -- Sex differences; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2022.101134
• Languages: English
• ISSNs: 1878-9293

Abstract

Abstract: The ultrafast spatiotemporal dynamics of large-scale neural networks can be examined using resting-state electroencephalography (EEG) microstates, representing transient periods of synchronized neural activity that evolve dynamically over time. In adults, four canonical microstates have been shown to explain most topographic variance in resting-state EEG. Their temporal structures are age-, sex- and state-dependent, and are susceptible to pathological brain states. However, no studies have assessed the spatial and temporal properties of EEG microstates exclusively during early childhood, a critical period of rapid brain development. Here we sought to investigate EEG microstates recorded with high-density EEG in a large sample of 103, 4–8-year-old children. Using data-driven k -means cluster analysis, we show that the four canonical microstates reported in adult populations already exist in early childhood. Using multiple linear regressions, we demonstrate that the temporal dynamics of two microstates are associated with age and sex. Source localization suggests that attention- and cognitive control-related networks govern the topographies of the age- and sex-dependent microstates. These novel findings provide unique insights into functional brain development in children captured with EEG microstates. Highlights: Resting-state EEG microstates are stable periods of scalp potential topographies. They reflect the activity of large-scale neural networks at the millisecond-level. Age and sex relate to the temporal dynamics of two microstates during early childhood. Their sources represent attention- and cognitive control-related networks. Microstates provide unique insights into brain development during early childhood.