Cyclic guanidine containing amino acids that promote glucocerebrosidase. (24th September 2022)

• Record Type: Journal Article
• Authors: Al-Taie, Zahraa S.; Bartholomew, Barbara; Coles, Simon J.; Evans, Daniel M.; Hollinshead, Jackie; Jones, Leigh F.; Kraehenbuehl, Rolf; Murphy, Patrick J.; Nash, Robert J.; Penkova, Yana B.; Tizzard, Graham J.
• Is Part Of: Tetrahedron. Volume 123(2022)
• Publication Date: 2022-09-24
• Subjects: Cyclic guanidines -- Glycosidase inhibitors -- Glycosidase promoters -- N-methylation; RZYQDFCBVBWREJ-DJHGXJLXSA-N -- LRJQFCYXGYOOTO-UHFFFAOYSA-M -- VUCYZAXAFHYSIY-KIFWWAFVSA-N -- KBURPLQLJFTMFQ-FQDRLZKGSA-N; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2022.132959
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Novel cyclic guanidine containing amino acids ( S )-1, 2 and 3 were prepared from l -serine 5 . ( S )-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2 . HCl and (3S, 6S)-3, 6-bis(hydroxymethyl)-1, 4-dimethylpiperazine-2, 5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase. Graphical abstract: Image 1