Γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy. (October 2022)

• Record Type: Journal Article
• Authors: Zhou, Yanfang; Chen, Piaoyi; Chen, Mianrong; Li, Jiesong; Li, Xufeng; Lin, Lingyin; Lun, Yingying; Li, Qiuxia; Xiao, Qinglin; Huang, Yugang; Wang, Xianshu; Zou, Hongzhi; Ye, Guodong
• Is Part Of: Materials & design. Volume 222(2022)
• Publication Date: 2022-10
• Subjects: Sucrose allyl ether -- Magnetic microsphere -- Magnetic resonance imaging -- Magnetothermal therapy; ALT alanine aminotransferase -- HFAMF high-frequency alternating magnetic field -- AO acridine orange -- AST aspartate aminotransferase -- BUN blood urea nitrogen -- CK creatine kinase -- CREA creatinine -- DCT degradable chain transfer -- DMEM dulbecco's modified eagle medium -- DTG the first derivative of the thermogravimetry -- EDS energy dispersive spectrometry -- FBS fetal bovine serum -- FTIR fourier transform infrared spectrometer -- H&E hematoxylin and eosin -- HMPP 2-hydroxy-2 methyl-1-phenyl-1-propanone -- IR infrared radiation -- KM kunming -- MRI magnetic resonance imaging -- MTT magnetothermal therapy -- PSAE polysucrose allyl ether, -- PI propidium iodide -- PBS phosphate buffer solution -- PVP polyvinyl pyrrolidone -- RGR relative growth rate -- RT-IR real-time fourier transform infrared -- γ-Fe2O3@PSAE γ-Fe2O3@polysucrose allyl ether, -- SAE sucrose multi-allyl ether -- SEM scanning electron microscope -- TG thermogravimetry -- VSM vibrating sample magnetometer; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2022.111062
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: Visualization and targeting can be achieved. Photopolymerization can prepare magnetic polymer materials at room temperature, avoiding the phenomenon of high temperature demagnetization caused by thermal polymerization. Inert allylic monomer materials are activated by light, which is expected to be widely used in the field of biomedical materials. Sucrose Allyl Ether monomers have polyhydroxy functional groups and enhanced polarity, which can disperse nano-magnetic inorganic substances. Abstract: Traditional magnetothermal nanoparticles showed great limitations for the diagnosis of tumor location in a dynamic physiological environment in vivo . Here, we show an one-step photo-click method based on the composite structure of γ-Fe2 O3 @Poly(sucrose allyl ether) magnetic microspheres to meet this challenge. The advantages are to prepare the magnetic microspheres not in extreme conditions and using sucrose as the polymeric matrix to prevent Fe2 O3 nanoparticles from agglomeration. A series of in vitro and in vivo experiments showed that γ-Fe2 O3 @PSAE has excellent stability in biological medium and inappreciable cytotoxicity. Moreover obvious tumor magnetic resonance imaging contrasts were observed based on response of γ-Fe2 O3 @PSAE. Under an alternating magnetic field, the heat generated by the magnetic microspheres γ-Fe2 O3 @PSAE thermally ablated H22 hepatoma cells from Kunming male mice, thereby inhibiting tumors. The histopathological studies showed that the tumor growth was significantly inhibited with the increase in the dosage of γ-Fe2 O3 @PSAE.