A Rare Association of Celiac Disease and Aplastic Anemia: Case Report of a Child and Review of Literature. (November 2014)

• Record Type: Journal Article
• Authors: Badyal, Rama Kumari; Sachdeva, Man Updesh Singh; Varma, Neelam; Thapa, Babu Ram
• Is Part Of: Pediatric and developmental pathology. Volume 17:Number 6(2014)
• Page Start: 470
• Page End: 473
• Publication Date: 2014-11
• Subjects: aplastic anemia -- celiac disease -- child -- gluten-free diet; Pediatric pathology -- Periodicals; Children -- Diseases -- Periodicals; Diagnosis, Laboratory -- Periodicals; Abnormalities, Human -- Periodicals; Child development -- Periodicals; Pediatrics -- Periodicals; 616.07
• DOI: 10.2350/14-05-1489-CR.1
• Languages: English
• ISSNs: 1093-5266

Abstract

An association between severe aplastic anemia and other autoimmune diseases is rare and has been described in adults for eosinophilic fasciitis, thymomas, systemic lupus erythematosus, and thyroid disorders. Herein we report a patient with celiac disease who was not strictly following a gluten-free diet and presented with progressive pallor, fever, and weakness of 1 month's duration. On investigation, he had pancytopenia, which on subsequent evaluation revealed aplastic anemia. An association between aplastic anemia and celiac disease has rarely been reported. To the best of author's knowledge, only 1 pediatric case of celiac disease associated with aplastic anemia has been published. This is the second report to suggest such an association in children.