Cyophiobiolins A-D, ophiobolin sestertepenoids from Cytospora rhizophorae. (November 2022)

• Record Type: Journal Article
• Authors: Zhang, Yanjiang; Liu, Hongxin; Chen, Yuchan; Lu, Xiuxiang; Liu, Zhaoming; Tan, Haibo; Zhang, Weimin
• Is Part Of: Phytochemistry. Volume 203(2022)
• Publication Date: 2022-11
• Subjects: Gynochthodes officinalis -- Rubiaceae -- Cytospora rhizophorae -- Valsaceae -- Endophytic fungus -- Cyophiobiolins -- Anti-inflammatory activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113352
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Cyophiobiolins A-D, four unreported ophiobolin-type sesterterpenoids, were isolated from Cytospora rhizophorae A761, an endophytic fungus from Gynochthodes officinalis . The structures of these undescribed compounds were fully characterized on the basis of extensively spectroscopic data (1D, 2D NMR and HRESIMS) and single-crystal X-ray diffraction analyses. Moreover, cyophiobiolins A-D were evaluated for in vitro cytotoxic, anti-inflammatory, and antibacterial activities. Cyophiobiolins A-B showed inhibitory potency against lipopolysaccharide (LPS)-induced oxide production with IC50 values of 66.3 μM and 53.3 μM, respectively. Graphical abstract: Cyophiobiolins A-D, four unreported ophiobolin-type sesterterpenoids, were isolated from Cytospora rhizophorae A761, an endophytic fungus from Gynochthodes officinalis . Image 1 Highlights: Four unreported ophiobolins were isolated from Cytospora rhizophorae A761. This is the first report of ophiobolin sestertepenoids type in Cytospora. Cyophiobiolins A-B displayed anti-inflammatory activity without cytotoxicity.