Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. (November 2022)

• Record Type: Journal Article
• Authors: Tang, Xiaoyuan; Zhao, Yuxuan; Wang, Xude; Ye, Chongtao; Feng, Baomin; Tang, Chuan; Lu, Xuan
• Is Part Of: Phytochemistry. Volume 203(2022)
• Publication Date: 2022-11
• Subjects: Rhodiola tibetica -- Crassulaceae -- Alternaria sp. HJT-Y7 -- Pleosporaceae -- Polyketide -- Anti-inflammatory -- Endophyte; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113383
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Seven undescribed polyketides with particular ortho-trisubstituted benzo[ c ]furan and benzo[ c ]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations. Graphical abstract: Seven undescribed compounds were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Image 1 Highlights: Seven undescribed compounds were isolated from Alternaria sp. HJT-Y7. Three compounds were ortho-trisubstituted benzo[ c ]furan diploid polymers. One compound was a 6/7/5/7/6 scaffold benzo[ c ]oxepin spiro. Six compounds exhibited the inhibition of NO production.