Comorbid amyloid‐β pathology affects clinical and imaging features in VCD. Issue 2 (4th January 2020)

• Record Type: Journal Article
• Authors: Leijenaar, Jolien F.; Groot, Colin; Sudre, Carole H.; Bergeron, David; Leeuwis, Anna E.; Cardoso, M. Jorge; Carrasco, Ferran Prados; Laforce, Robert; Barkhof, Frederik; van der Flier, Wiesje M.; Scheltens, Philip; Prins, Niels D.; Ossenkoppele, Rik
• Is Part Of: Alzheimer's & dementia. Volume 16:Issue 2(2020)
• Page Start: 354
• Page End: 364
• Publication Date: 2020-01-04
• Subjects: Amyloid‐β -- Cognition -- Gray matter atrophy -- MRI -- Vascular cognitive disorders -- Vascular dementia -- White matter hyperintensities; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2019.08.190
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: To date, the clinical relevance of comorbid amyloid‐β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild‐VCD (n = 84), Aβ− mild‐VCD (n = 68), Aβ+ major‐VCD (n = 31), and Aβ− major‐VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI. Results: Aβ− patients showed more depressive symptoms than Aβ+. In the major‐VCD group, Aβ− patients performed worse on attention ( P = .02) and executive functioning ( P = .008) than Aβ+. We found no cognitive differences in patients with mild VCD. In the mild‐VCD group, Aβ− patients had more WMH than Aβ+ patients, whereas conversely, in the major‐VCD group, Aβ+ patients had more WMH. Atrophy patterns did not differ between Aβ+ and Aβ− VCD group. Discussion: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD.