Helicobacter Pylori HP0175 Promotes the Production of IL-23, IL-6, IL-1β and TGF-β. (January 2013)

• Record Type: Journal Article
• Authors: Amedei, A.; Munari, F.; Della Bella, C.; Niccolai, E.; Benagiano, M.; Bencini, L.; Cianchi, F.; Silvestri, E.; D'Elios, S.; Farsi, M.; Prisco, D.; Zanotti, G.; De Bernard, M.; Kundu, M.; D'Elios, M.M.
• Is Part Of: European journal of inflammation. Volume 11:Number 1(2013)
• Page Start: 261
• Page End: 268
• Publication Date: 2013-01
• Subjects: Helicobacter pylori -- cytokines -- IL-23 -- IL-lb -- IL-6 -- TGF-b; Inflammation -- Periodicals; Anti-Inflammatory Agents -- therapeutic use -- Periodicals; Immunotherapy -- Periodicals; Inflammation -- Periodicals; Anti-inflammatory agents -- Periodicals; Immunotherapy -- Periodicals; Anti-inflammatory agents; Immunotherapy; Inflammation; Periodicals; 616.0473
• DOI: 10.1177/1721727X1301100127
• Languages: English
• ISSNs: 1721-727X

Abstract

Helicobacter pylori infection induces a chronic gastric inflammatory infiltrate. This study was undertaken to evaluate the type of the innate immune responses elicited by the secreted peptidyl-prolyl cis-trans isomerase of H. pylori (HP0175). The cytokine production induced by HP0175 in neutrophils, and monocytes was evaluated. HP0175 was able to induce the expression of IL-23 in neutrophils, and monocytes, and IL-6, IL-1beta and TGF-beta in monocytes. These findings indicate that HP0175 is able to promote the activation of innate cells and the production of a cytokine milieu that may favour the development of Th17 response.