Copper‐Catalyzed Direct Oxidative α‐Alkoxylation of 4‐Isochromanones. Issue 17 (5th May 2021)

• Record Type: Journal Article
• Authors: Wu, Xiang; Song, Shuang‐Gui; Zhang, Xin; Fu, Yan‐Ming; Zhu, Cheng‐Feng; Li, You‐Gui
• Is Part Of: European journal of organic chemistry. Issue 17(2021)
• Page Start: 2436
• Page End: 2439
• Publication Date: 2021-05-05
• Subjects: Alkoxylation -- C−O bond -- Copper -- Oxidative cross-coupling -- 3-Oxy-4-isochromanones; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100243
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: The direct oxidative α‐alkoxylation of carbonyl compounds is very important, highly desirable but relatively rare. A general and convenient approach has been developed to prepare 3‐oxy‐4‐isochromanones by copper‐catalyzed α‐C(sp 3 )−H alkoxylation of 4‐isochromanones with alcohols. The key features are easily available starting materials, mild reaction conditions, broad substrate scope, and excellent regioselectivity. Abstract : A general and convenient approach to prepare 3‐oxy‐4‐isochromanones has been developed by copper‐catalyzed α‐C(sp 3 )−H alkoxylation of 4‐isochromanones with alcohols. The key features are easily available starting materials, mild reaction conditions, broad substrate scope, and excellent regioselectivity.