Circadian Control of Glial Cell Homeodynamics. Issue 6 (December 2022)

• Record Type: Journal Article
• Authors: Rojo, Daniela; Badner, Anna; Gibson, Erin M.
• Is Part Of: Journal of biological rhythms. Volume 37:Issue 6(2022)
• Page Start: 593
• Page End: 608
• Publication Date: 2022-12
• Subjects: circadian -- astrocytes -- microglia -- oligodendroglia -- neurodegeneration; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.1177/07487304221120966
• Languages: English
• ISSNs: 0748-7304

Abstract

The molecular mechanisms that maintain circadian rhythms in mammalian as well as non-mammalian systems are well documented in neuronal populations but comparatively understudied in glia. Glia are highly dynamic in form and function, and the circadian clock provides broad dynamic ranges for the maintenance of this homeostasis, thus glia are key to understanding the role of circadian biology in brain function. Here, we highlight the implications of the molecular circadian clock on the homeodynamic nature of glia, underscoring the current gap in understanding the role of the circadian system in oligodendroglia lineage cells and subsequent myelination. Through this perspective, we will focus on the intersection of circadian and glial biology and how it interfaces with global circadian rhythm maintenance associated with normative and aberrant brain function.