TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case–control study. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: Azmerin, Maria; Hussain, Md. Saddam; Aziz, Md. Abdul; Barek, Md. Abdul; Begum, Mobashera; Sen, Niloy; Rahman, Md. Abdur; Shahriar, Mohammad; Baeesa, Saleh Salem; Ashraf, Ghulam Md; Islam, Mohammad Safiqul
• Is Part Of: Journal of international medical research. Volume 50:Issue 11(2022)
• Publication Date: 2022-11
• Subjects: Autism spectrum disorder -- polymerase chain reaction -- restriction fragment length polymorphism -- genetic polymorphism -- TF rs1867503 -- TCF4 rs9951150 -- mutant allele G; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605221138492
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case–control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively. Methods: Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction–restriction fragment length polymorphism technique was applied for genotyping. Results: The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR = 3.18), GG mutant homozygotes (OR = 2.62), AG + GG combined genotypes (OR = 2.98), and G mutant alleles of TF rs1867503 (OR = 1.94) were associated with a significantly elevated risk of ASD. Likewise, AG heterozygotes (OR = 2.92), GG mutant homozygotes (OR = 2.36), AG + GG combined genotypes (OR = 2.72), and G minor alleles of TCF4 rs9951150 (OR = 1.92) were associated with a significantly elevated risk of ASD. Conclusions: Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms may be strongly associated with the development of ASD in Bangladeshi children.