Lamotrigine induced priapism in children: case analysis and literature review. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: Ge, Jie; Cao, Shan-Shan; Cao, Xiao-Yu; Tang, Meng; Mu, Fei; Qiao, Yi; Guan, Yue; Wang, Jing-Wen
• Is Part Of: Journal of international medical research. Volume 50:Issue 11(2022)
• Publication Date: 2022-11
• Subjects: Lamotrigine -- priapism -- children -- case report; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605221133988
• Languages: English
• ISSNs: 0300-0605

Abstract

Lamotrigine is an antiepileptic drug that can be used to control many types of seizures as a single-agent or an add-on therapy in patients over 2 years of age. In addition to common adverse reactions, this current case report describes a paediatric male patient with a rare side-effect of persistent penile erectile due to lamotrigine. Previous studies have shown that it can improve sexual function in adult male patients. This patient suffered from refractory epilepsy and pneumonia. He had taken a variety of antiepileptic drugs for a long time and developed priapism after the dosage of lamotrigine had been increased. The priapism improved after drug withdrawal and sedation. Further research is needed to elucidate the mechanism of this rare side-effect.