Imaging features, staging system, and surgical management of giant cell lesions of the temporal bone. (3rd August 2022)

• Record Type: Journal Article
• Authors: Li, Xiaohong; Wen, Yi; Zhang, Jie; Wu, Nan; Shen, Weidong; Yang, Shiming; Dai, Pu; Han, Dongyi; Yang, Yang; Han, Weiju; Feng, Bo; Wang, Guojian
• Is Part Of: Acta oto-laryngologica. Volume 142:Number 7/8(2022)
• Page Start: 553
• Page End: 561
• Publication Date: 2022-08-03
• Subjects: Giant cell tumor (GCT) -- Giant cell granuloma (GCG) -- Temporal bone -- Infratemporal fossa -- Skull base -- Middle cranial fossa approach; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2022.2099969
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Giant cell tumors (GCTs) and giant cell granulomas (GCGs) are giant cell-rich lesions that occur extremely rarely in the temporal bone and have similar clinical presentations. Objectives: We aimed to analyze the clinical features and introduce our staging system and surgical treatment. Methods: Forty-six patients pathologically diagnosed with a giant cell lesion involving the temporal bone between October 2001 and October 2020 were reviewed retrospectively. The clinical characteristics, surgical approaches, and risk factors for recurrence were analyzed. Results: GCTs and GCGs presented as masses centered on the temporomandibular joint with similar imaging features, including a thin, calcified shell and central scattered calcifications on a computed tomography scan. Differences were detected on magnetic resonance imaging in 29.6% (4/14) of GCG and 50% (16/32) of GCT cases; the remaining cases were not distinguishable. Based on our staging system and surgical strategy, 31.8% (7/22) of GCT and 10% (1/10) of GCG cases experienced recurrence, which compares to recurrence rates of 60% in GCT cases and 20% in GCG cases in previous studies. Conclusions: Specific clinical and preoperative imaging features help to make a diagnosis of temporal giant cell-rich lesions. Our staging system and surgical strategy could help surgeons tailor the surgical strategy.