59 Effects of Feeding Nutragen on Clinical Signs and Leukocytes in Calves Following Natural Exposure to Bovine Viral Diarrhea Virus and Subsequent Mannheimia Haemolytica Infection. (21st September 2022)

• Record Type: Journal Article
• Authors: Markey, Jazmin A; Gong, Wendy; Schneid, Kasi N; Liuzzo, Avianna; Farran, Garrett; Rudd, Jennifer; Snider, Tim; Montelongo, Marie; Humphrey, Brooke; Chapman, James D; Sharman, Evin D; Garcia, Miriam; Reuter, Ryan R; Beck, Paul A; Foote, Andrew P; Bruno, Kelsey; Wilson, Blake K
• Is Part Of: Journal of animal science. Volume 100(2022)Supplement 3
• Page Start: 26
• Page End: 27
• Publication Date: 2022-09-21
• Subjects: bovine respiratory disease -- challenge -- feed additive -- Mannheimia haemolytica; Livestock -- Periodicals; Livestock; Electronic journals; Periodicals; 636.005
• DOI: 10.1093/jas/skac247.049
• Languages: English
• ISSNs: 0021-8812

Abstract

Abstract: Two experiments (EXP1 and EXP2) evaluated the effects of NutraGen (NG) on calf health following exposure to bovine viral diarrhea virus (BVDV) on d -3 and Mannheimia haemolytica (Mh) infection on d 0. For each EXP, steers (BW = 251 ± 38.2 kg) were randomly allocated to 1 of 3 treatments (TRT). Treatments included a placebo (CON; EXP1 n = 5; EXP2 n = 5), a placebo fed from d -18 to d -3 followed by NG fed from d -3 to d 28 (CHLG; EXP1 n = 5; EXP2 n = 6), and NG fed from d -18 to d 28 (PREC; EXP1 n = 6; EXP2 n = 5). There was no treatment by time interaction (TRT×TME) or TRT effect for rectal temperatures (RT) or clinical scores (CS) in EXP1 or CS in EXP2 (P ≥ 0.26). There was a TRT×TME for respiration rates (RR) during the first 24 h following Mh infection (P = 0.04), and a tendency for a TRT effect from d -3 to d 14, and overall in EXP1 (P ≤ 0.10). There was a tendency for a TRT×TME for RT from d -3 to d 14 in EXP2 (P = 0.04). There was a TRT effect for RR from d -3 to d 14 and overall in EXP2 (P ≤ 0.05). There was a TRT×TME for leukocytes during the first 24 h following Mh infection in EXP1 (P = 0.03) and overall in both EXP (P ≤ 0.001). There was no TRT×TME or TRT effect for neutrophils (NEU), lymphocytes (LYM), or NEU:LYM in EXP1 (P ≥ 0.19); however, there were multiple TRT×TME and TRT effects for NEU, LYM, and NEU:LYM in EXP2 (P ≤ 0.05). These experiments suggest that NG has the potential to alter clinical and cellular responses during a bovine respiratory disease challenge.