A case of presumed herpes keratouveitis in a patient treated with fingolimod. (3rd June 2016)

• Record Type: Journal Article
• Authors: Ayers, Malissa C; Conway, Devon S
• Is Part Of: Multiple sclerosis journal, experimental, translational and clinical. Volume 2(2016)
• Publication Date: 2016-06-03
• Subjects: Multiple sclerosis -- fingolimod -- adverse events -- disease-modifying therapies; Multiple sclerosis -- Periodicals; 616.834
• DOI: 10.1177/2055217316652907
• Languages: English
• ISSNs: 2055-2173

Abstract

We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation.