Ventriculitis and meningitis: by methicillin-resistant S. epidermidis: comparison of serum and CSF vancomycin concentrations and possible effect on MIC. (20th September 2022)

• Record Type: Journal Article
• Authors: Sette, Claudia; Parodi, Alessandro; Barco, Sebastiano; Castagnola, Elio
• Is Part Of: Journal of chemotherapy. Volume 34:Number 6(2022)
• Page Start: 414
• Page End: 415
• Publication Date: 2022-09-20
• Subjects: HCAMV -- vancomycin -- linezolid; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1080/1120009X.2022.2066782
• Languages: English
• ISSNs: 1120-009X

Abstract

Abstract: A case of HCAMV due to methicillin-resistant S. epidermidis (MRSE) in a new-born treated with vancomycin is described. Despite adequate vancomycin serum concentrations, an increase in vancomycin MIC (from 1 to 2 mg/L) in presence of persistently low CSF concentrations were observed. The eGFR during the treatment period was normal (no evidence of hyperfiltration). This report confirms the observation of a relationship among antibiotic PK/PD, cure of localized infections and resistance selection and specifically suggests the need for a first-line alternative to vancomycin in case of HCAMV due to CoNS with MIC ≥ 1 mg/L.