Diversity Oriented Synthesis of Oxygen-Heterocycles, Warfarin Analogs Utilizing Microwave-Assisted Dimethyl Urea-Based Deep Eutectic Solvents. (9th August 2022)

• Record Type: Journal Article
• Authors: Teja, Chitrala; Garg, Ashna; Rohith, G.K.; Roshini, Hanumanthu; Jena, Sushovan; Nawaz Khan, Fazlur Rahman
• Is Part Of: Polycyclic aromatic compounds. Volume 42:Number 7(2022)
• Page Start: 4769
• Page End: 4779
• Publication Date: 2022-08-09
• Subjects: Benzopyrans -- deep eutectic solvents -- pyranocoumarins -- warfarin analogs -- xanthenes; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2021.1912123
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: Deep eutectic solvent (DES) catalyzed, Microwave-assisted one-pot conjugate Michael addition followed by annulation of nucleophiles, 4-hydroxy coumarin, 1, 3-diketone with α, β-unsaturated carbonyl compounds (chalcones) toward benzopyran, pyranocoumarin, xanthene, dihydrofuran, 4-hydroxy-coumarin (warfarin analogs) derivatives has been achieved. It is a one-pot, solvent, metal-free, and green chemical approach with a clean reaction pathway, in high regio, stereo selectivities, and yields under milder MW-irradiation. The easily recoverable DES catalyst and eco-friendly reaction strategy are notable advantages of the current procedure.