Bioassay-guided isolation of vilasinin–type limonoids and phenyl alkene from the leaves of Trichilia gilgiana and their antiplasmodial activities. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Kowa, Théodora K.; Jansen, Olivia; Ledoux, Allison; Mamede, Lucia; Wabo, Hippolyte K.; Tchinda, Alembert T.; Genta-Jouve, Gregory; Frédérich, Michel
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 5039
• Page End: 5047
• Publication Date: 2022-09-21
• Subjects: Trichilia gilgiana -- limonoids -- phenyl alkene -- antiplasmodial activity -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1920017
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Bioassay-guided fractionation of the CH2 Cl2 -MeOH (1:1) leaves extract of Trichilia gilgiana, yielded two new vilasinin-type limonoids named gilgianin A (1 ) and gilgianin B (2 ), one new phenyl alkene derivative designated as gilgialkene A (3 ), along with six known compounds: rubescin H (4 ), TS3 (5 ), trichirubine A (6 ), sitosteryl-6′- O -undecanoate- β -D-glucoside (7 ), scopoletin (8 ), and octadecane-2-one (9 ). Their structures were elucidated based on spectroscopic analysis and comparison with literature data. Compounds 5 and 6 exhibited the highest antiplasmodial activity with IC50 values of 1.14 and 1.32 μM respectively. Moreover, compound 5 was very cytotoxic with CC50 value of 0.88 µM, compared to compound 6, which was not cytotoxic (CC50 > 10 µg/mL). Compounds 1 ( IC50 = 9.84 µM), 2 (IC50 = 11.04 µM) and 4 (IC50 = 10.71 µM) presented good antiplasmodial activity while also exhibiting significant cytotoxicity, with CC50 values ranging from of 14.45 to 29.7 µM.