Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality. (20th August 2022)

• Record Type: Journal Article
• Authors: Rocco, Joseph M; Laghetti, Paola; Di Stefano, Mariantonietta; Sereti, Irini; Ortega-Villa, Ana; Wang, Jing; Rupert, Adam; Chironna, Maria; Ye, Lara; Liu, Xiangdong; Anderson, Megan V; Burbelo, Peter B; Fiore, Jose Ramon; Saracino, Annalisa; Lisco, Andrea
• Is Part Of: Open forum infectious diseases. Volume 9:Number 9(2022)
• Publication Date: 2022-08-20
• Subjects: COVID-19 -- endothelial damage -- inflammation -- metabolic biomarkers; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac427
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.