Past, present, and future of allergen immunotherapy vaccines. Issue 1 (29th April 2020)
- Record Type:
- Journal Article
- Title:
- Past, present, and future of allergen immunotherapy vaccines. Issue 1 (29th April 2020)
- Main Title:
- Past, present, and future of allergen immunotherapy vaccines
- Authors:
- Dorofeeva, Yulia
Shilovskiy, Igor
Tulaeva, Inna
Focke‐Tejkl, Margarete
Flicker, Sabine
Kudlay, Dmitriy
Khaitov, Musa
Karsonova, Antonina
Riabova, Ksenja
Karaulov, Alexander
Khanferyan, Roman
Pickl, Winfried F.
Wekerle, Thomas
Valenta, Rudolf - Abstract:
- Abstract: Allergen‐specific immunotherapy (AIT) is an allergen‐specific form of treatment for patients suffering from immunoglobulin E (IgE)‐associated allergy; the most common and important immunologically mediated hypersensitivity disease. AIT is based on the administration of the disease‐causing allergen with the goal to induce a protective immunity consisting of allergen‐specific blocking IgG antibodies and alterations of the cellular immune response so that the patient can tolerate allergen contact. Major advantages of AIT over all other existing treatments for allergy are that AIT induces a long‐lasting protection and prevents the progression of disease to severe manifestations. AIT is cost effective because it uses the patient´s own immune system for protection and potentially can be used as a preventive treatment. However, broad application of AIT is limited by mainly technical issues such as the quality of allergen preparations and the risk of inducing side effects which results in extremely cumbersome treatment schedules reducing patient´s compliance. In this article we review progress in AIT made from its beginning and provide an overview of the state of the art, the needs for further development, and possible technical solutions available through molecular allergology. Finally, we consider visions for AIT development towards prophylactic application.
- Is Part Of:
- Allergy. Volume 76:Issue 1(2021)
- Journal:
- Allergy
- Issue:
- Volume 76:Issue 1(2021)
- Issue Display:
- Volume 76, Issue 1 (2021)
- Year:
- 2021
- Volume:
- 76
- Issue:
- 1
- Issue Sort Value:
- 2021-0076-0001-0000
- Page Start:
- 131
- Page End:
- 149
- Publication Date:
- 2020-04-29
- Subjects:
- allergen -- allergen‐specific immunotherapy -- allergy -- molecular allergy vaccines
Allergy -- Periodicals
616.97 - Journal URLs:
- http://estar.bl.uk/cgi-bin/sciserv.pl?collection=journals&journal=01054538 ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1398-9995 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/all.14300 ↗
- Languages:
- English
- ISSNs:
- 0105-4538
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0790.945000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 23926.xml