Predictors of Hospitalization and Superinfection in Viral Respiratory Tract Infections Between Influenza and Paramyxoviruses: The SUPERFLUOUS Study . (12th October 2021)

• Record Type: Journal Article
• Authors: Lemarie, Benoit; Boussaid, Ghilas; Gault, Elyanne; Prigent, Helene; Beaune, Sebastien; Moreau, Frederique; Dumoulin, Jennifer; Pepin, Marion; Greffe, Segolene; De Truchis, Pierre; Davido, Benjamin
• Is Part Of: Journal of infectious diseases. Volume 226:Number 6(2022)
• Page Start: 1027
• Page End: 1035
• Publication Date: 2021-10-12
• Subjects: Bacteria -- influenza -- respiratory tract infections -- Superinfection -- Viruses; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab525
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Viral respiratory tract infections (VRTIs) are among the most common diseases, but the risks of superinfection for different virus species have never been compared. Methods: Multicenter retrospective study conducted among adults who tested positive for VRTIs with reverse-transcription polymerase chain reaction. We compared characteristics between influenza (A or B) and paramyxoviruses (respiratory syncytial virus, parainfluenza virus types 1 and 3, and human metapneumovirus) and identified predictors of superinfection and hospitalization.s Results: Five hundred ninety patients had VRTI, including 347 (59%) influenza and 243 paramyxovirus infections with comparable rates of superinfections (53% vs 60%). In multivariate analyses, the predictors of superinfections were age >75 years (adjusted odds ratio, 2.37 [95% confidence interval, 1.65–3.40]), chronic respiratory disease (1.79 [1.20–2.67]), and biological abnormalities, including neutrophil count >7000/µL (1.98 [1.34–2.91)], eosinophil count <50/µL (2.53 [1.61–3.98], and procalcitonin level >0.25ng/mL (2.8 [1.65–4.73]). The predictors of hospitalization were age >75 years old (adjusted odds ratio, 3.49 [95% confidence interval, 2.17–5.63]), paramyxovirus infection (2.28 [1.39–3.75]), long-term use of inhaled corticosteroids (2.49 [1.13–5.49]), and biological abnormalities, including neutrophil count >7000/µL (2.38 [1.37–4.12)] and procalcitonin level >0.25ng/mL (2.49 [1.23–5.02]). Kaplan-Meier survival curves showed that influenza-infected patients had a higher mortality rate than those with paramyxovirus infections (8.9% vs 4.5%, respectively; P = .02). Conclusions: Our study revealed a high rate of superinfection (56%), not related to viral species. However influenza virus was associated with a poorer prognosis than paramyxoviruses, pleading for a broader and large-scale vaccination of individual at risk of VRTIs. Abstract : In our in-hospital setting study, viral respiratory tract infections are at high risk of superinfection (56%), regardless of virus species, and require improving vaccination coverage among patients at risk.