Intrahepatic icterus in pigs: rare clinical sign in porcine circovirus type 2 systemic disease. Issue 3 (30th August 2020)

• Record Type: Journal Article
• Authors: Graage, Robert; Saura Martinez, Helena; Klausmann, Stefanie; Kubacki, Jakub; Kümmerlen, Dolf
• Is Part Of: Veterinary record case reports. Volume 8:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-30
• Subjects: porcine dermatitis and nephropathy syndrome (PDNS) -- porcine circovirus -- jaundice -- liver -- immunohistochemistry -- PCR; Veterinary medicine -- Case studies -- Periodicals; Veterinary medicine -- Periodicals; 636.08905
• DOI: 10.1136/vetreccr-2020-001193
• Languages: English
• ISSNs: 2052-6121

Abstract

SUMMARY: Icterus is a yellow discolouration of tissue and blood plasma due to a disorder of the bilirubin metabolism. This case report describes two porcine circovirus type 2 (PCV2) outbreaks in a fattening farm (F1) and a breeding farm (F2). At F1, pigs had intradermal bleedings and wasting, and three pigs showed icterus. At F2, suckling and weaning pigs (WPs) had an icterus and were wasted. Three fattening pigs (F1), one suckling piglet and one WP (F2) were dissected. Additional investigations included histology, PCV2 immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH) of tissue samples, PCR including sequencing of the PCV2 strains and next‐generation sequencing (NGS) of liver samples. Three of the five dissected pigs showed a lymphohistiocytic, periportal hepatitis with disruption of the hepatic cord architecture. PCV2 was detected by IHC, FISH, PCR and NGS in several organs of the pigs. In both farms, sequencing revealed a PCV2b genotype.