Biphasic Waning of Hemagglutination Inhibition Antibody Titers After Influenza Vaccination in Children. (5th April 2022)

• Record Type: Journal Article
• Authors: Xiong, Weijia; Tsang, Tim K; Perera, Ranawaka A P M; Leung, Nancy H L; Fang, Vicky J; Barr, Ian G; Malik Peiris, J S; Cowling, Benjamin J
• Is Part Of: Journal of infectious diseases. Volume 226:Number 6(2022)
• Page Start: 1022
• Page End: 1026
• Publication Date: 2022-04-05
• Subjects: antibody -- waning -- influenza -- vaccine -- children; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac117
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children and tested them with hemagglutination inhibition assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effects models, we found evidence for a faster initial waning of antibody titers for the first 1–2 years after vaccination and then slower longer-term declines. Children with higher postvaccination titers had faster antibody decay. Abstract : We explored the biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children. We found evidence for a faster waning for the first 1–2 years and then slower longer-term declines. Children with higher postvaccination titers had faster antibody decay.