A new flavonoid from the leaves of Garcinia mckeaniana Craib and α-glucosidase and acetylcholinesterase inhibitory activities. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Nguyen, Thi Thu Ha; Nguyen, Van Tuyen; Van Cuong, Pham; Nguyen Thanh, Tra; Le Thi, Tu Anh; Mai Huong, Doan Thi; Truong, Bich Ngan; Litaudon, Marc; Ninh The, Son
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 5074
• Page End: 5080
• Publication Date: 2022-09-21
• Subjects: Garcinia mckeaniana -- flavonoids -- α-glucosidase -- acetylcholinesterase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1916019
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: From the ethyl acetate extract (EtOAc) of the Vietnamese Garcinia mckeaniana leaves, a new flavone 8- C -glycoside 2'', 6''-di- O -acetylvitexin (1 ), together with six known analogs 2-7 were isolated. Their structures were determined by spectral methods and compared with literature data. In α-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 µM, as compared with that of the positive control acarbose (249 µM). Flavones and biflavones showed are better than flavone glycosides in both α-glucosidase and acetylcholinesterase inhibitory activities