Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice. (11th July 2022)

• Record Type: Journal Article
• Authors: Kataoka, Takahiro; Ishida, Tsuyoshi; Naoe, Shota; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro; Yamaoka, Kiyonori
• Is Part Of: Journal of radiation research. Volume 63:Number 5(2022)
• Page Start: 719
• Page End: 729
• Publication Date: 2022-07-11
• Subjects: alcohol-induced liver damage -- oxidative stress -- antioxidative function -- ascorbic acid (AA) -- thoron; Radiology, Medical -- Periodicals; Radiobiology -- Periodicals; Radiation -- Periodicals; 616.0757
• DOI: 10.1093/jrr/rrac046
• Languages: English
• ISSNs: 0449-3060

Abstract

Abstract: Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m 3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m 3 ) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m 3 ) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m 3 thoron inhalation was lower than that after 500 Bq/m 3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m 3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m 3 was more effective than that at 2000 Bq/m 3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m 3 and AA administration promoted an early recovery from alcohol-induced liver damage.