Prediction of biomarker–disease associations based on graph attention network and text representation. Issue 5 (29th July 2022)

• Record Type: Journal Article
• Authors: Yang, Minghao; Huang, Zhi-An; Gu, Wenhao; Han, Kun; Pan, Wenying; Yang, Xiao; Zhu, Zexuan
• Is Part Of: Briefings in bioinformatics. Volume 23:Issue 5(2022)
• Publication Date: 2022-07-29
• Subjects: miRNA–disease associations -- microbe–disease associations -- lncRNA–disease associations -- graph attention network -- text-based relation representation -- bimodal fusion network; Genetics -- Data processing -- Periodicals; Molecular biology -- Data processing -- Periodicals; Genomes -- Data processing -- Periodicals; 572.80285
• DOI: 10.1093/bib/bbac298
• Languages: English
• ISSNs: 1467-5463

Abstract

Abstract: Motivation: The associations between biomarkers and human diseases play a key role in understanding complex pathology and developing targeted therapies. Wet lab experiments for biomarker discovery are costly, laborious and time-consuming. Computational prediction methods can be used to greatly expedite the identification of candidate biomarkers. Results: Here, we present a novel computational model named GTGenie for predicting the biomarker–disease associations based on graph and text features. In GTGenie, a graph attention network is utilized to characterize diverse similarities of biomarkers and diseases from heterogeneous information resources. Meanwhile, a pretrained BERT-based model is applied to learn the text-based representation of biomarker–disease relation from biomedical literature. The captured graph and text features are then integrated in a bimodal fusion network to model the hybrid entity representation. Finally, inductive matrix completion is adopted to infer the missing entries for reconstructing relation matrix, with which the unknown biomarker–disease associations are predicted. Experimental results on HMDD, HMDAD and LncRNADisease data sets showed that GTGenie can obtain competitive prediction performance with other state-of-the-art methods. Availability: The source code of GTGenie and the test data are available at: https://github.com/Wolverinerine/GTGenie .