2-Oxaspiro[4.5]decane and α-pyrenocine derivatives from the endophytic fungus Roussoella sp. PSU-H51. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Sommart, Ubonta; Rukachaisirikul, Vatcharin; Saithong, Saowanit; Phongpaichit, Souwalak; Sakayaroj, Jariya; Preedanon, Sita; Chainok, Kittipong; Khunrong, Teerayut
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 4911
• Page End: 4920
• Publication Date: 2022-09-21
• Subjects: Roussoella sp -- endophytic fungus -- oxaspiro derivative -- pyrenocine derivative -- cytotoxicity -- antifungal activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1910692
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new 2-oxaspiro[4.5]decane, roussoellide, and one new α- pyrenocine, 2 ', 3 ' -dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E, were obtained from the culture broth of the endophytic fungus Roussoella sp. Their structures were determined using spectroscopic data. The absolute configuration of known arthropsolide A was assigned on the basis of X-ray diffraction data using Cu K α radiation. Known pyrenocine A displayed weak cytotoxic activity against breast cancer (MCF-7) cells with an IC50 value of 27.1 µ M and weak antifungal activity against Microsporum gypseum SH-MU-4 with an MIC value of 615.2 µ M.