Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). (29th April 2019)

• Record Type: Journal Article
• Authors: Andrés, Cristina; Guasch, Eulàlia; Piñana, Maria; Fernandes, Paula; Gimferrer, Laura; Esso, Diego Van; Codina, Maria Gema; Esperalba, Juliana; Vila, Jorgina; Rodrigo, Carlos; Martín, Maria Carmen; Fuentes, Francisco; Rubio, Susana; Pumarola, Tomàs; Antón, Andrés
• Is Part Of: Future microbiology. Volume 14:Number 6(2019)
• Page Start: 499
• Page End: 507
• Publication Date: 2019-04-29
• Subjects: coxsackievirus A6 -- enteroviruses -- hand, food and mouth disease -- herpangina -- pediatric infections; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2018-0336
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017–2018 season.Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events.Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol.Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.