Three new indole diterpenoids from Aspergillus aculeatus KKU-CT2. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Chaiyosang, Boonyanoot; Kanokmedhakul, Kwanjai; Yodsing, Natanong; Boonlue, Sophon; Yang, Jian-Xiong; Wang, Yan Alexander; Andersen, Raymond J.; Yahuafai, Jantana; Kanokmedhakul, Somdej
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 4973
• Page End: 4981
• Publication Date: 2022-09-21
• Subjects: Aspergillus -- Aspergillus aculeatus -- indole diterpenoid -- aculeatupene -- cytotoxicity -- antibacterial; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1914613
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new indole diterpenoids, aculeatupenes A–C (1 –3 ), together with four known compounds (4 –7 ), were isolated from the mycelium of Aspergillus aculeatus KKU-CT2. Their structures were established by spectroscopic evidence and absolute configurations of 1 –3 were determined by comparison of their experimental and calculated ECD spectra. Compounds 1, 2, and emindole SB (4 ) showed weak cytotoxicity against HelaS3, KB, HepG2, MCF-7, and A549 cancer cell lines with IC50 values in the range of 11.12–67.81 μM. Compound 3 showed weak cytotoxicity against HelaS3 cell lines with an IC50 value of 17.48 μM but non-cytotoxicity against Vero cell line. In addition, compound 1 exhibited weak antibacterial activity against Bacillus cereus.