SUMO conjugation regulates immune signalling. Issue 1 (1st October 2020)

• Record Type: Journal Article
• Authors: Hegde, Sushmitha; Soory, Amarendranath; Kaduskar, Bhagyashree; Ratnaparkhi, Girish S.
• Is Part Of: Fly. Volume 14:Issue 1/4(2020)
• Page Start: 62
• Page End: 79
• Publication Date: 2020-10-01
• Subjects: Immunity -- ptm -- signal transduction -- sim -- ubiquitin -- transcriptional Activation/Repression -- crosstalk -- CRISPR -- nfκb; Drosophila -- Periodicals; 595.77
• DOI: 10.1080/19336934.2020.1808402
• Languages: English
• ISSNs: 1933-6934

Abstract

ABSTRACT: Post-translational modifications (PTMs) are critical drivers and attenuators for proteins that regulate immune signalling cascades in host defence. In this review, we explore functional roles for one such PTM, the small ubiquitin-like modifier (SUMO). Very few of the SUMO conjugation targets identified by proteomic studies have been validated in terms of their roles in host defence. Here, we compare and contrast potential SUMO substrate proteins in immune signalling for flies and mammals, with an emphasis on NFκB pathways. We discuss, using the few mechanistic studies that exist for validated targets, the effect of SUMO conjugation on signalling and also explore current molecular models that explain regulation by SUMO. We also discuss in detail roles of evolutionary conservation of mechanisms, SUMO interaction motifs, crosstalk of SUMO with other PTMs, emerging concepts such as group SUMOylation and finally, the potentially transforming roles for genome-editing technologies in studying the effect of PTMs.